Job Description

Scientist / Sr. Scientist, Discovery Research & Development

Direct Hire Full-Time Role

Salary Range: $104,000 - $145,600 per year

Location: Berkeley, CA - Onsite Role

Job Summary:

As a Scientist / Sr. Scientist on the discovery research & development team, the selected candidate will be responsible for designing and executing experiments that evaluate the efficacy of therapeutic cargo candidates and will play a crucial role in advancing our therapeutic products from discovery to the clinic.

Duties and Responsibilities:

• Design and execute laboratory experiments while following defined protocols and procedures. Troubleshoot and update protocols and procedures as needed.
• Perform molecular, cellular, and virological techniques including (but not limited to) molecular cloning; DNA/RNA/protein purification; PCR; qPCR; western blot; ELISA; immunofluorescence; next-generation sequencing preparation and data analysis; cancer cell culture maintenance, amplification, and transfection; and genetic manipulation, isolation, amplification, purification, titration, and transduction of poxvirus or lentivirus-based viral vectors; and inoculation of murine models with experimental cancer therapeutics.
• Analyze and interpret scientific data to drive decision-making and prioritization of therapeutic product candidates.
• Maintain a current knowledge of preclinical and clinical oncolytic virotherapy and cancer biology literature.
• Contribute to the development of project timelines.
• Interface with other groups such as the CMC/In Vivo team to support cross-functional initiatives.
• Maintain accurate and well-organized experimental records, including electronic laboratory notebooks.
• Write, edit, and review preclinical study reports, manuscripts, and preclinical sections of documents in support of regulatory submissions.
• Maintain compliance with the institution's Environmental Health & Safety policies.
• Commit to building and maintaining a company culture that promotes inclusivity, teamwork, strong work ethic, critical thinking, and innovation.

Requirements and Qualifications:

• A Ph.D. with 1-5 years of post-graduate industry experience in molecular or cellular biology, virology, biochemistry, bioengineering, or a closely related field.
• Prior experience and willingness to work with viral vectors and in vivo murine research models.
• Prior scientific productivity as evidenced by authorship of research publications.
• Ability to function independently to design, develop, and execute new assays.
• Rigorous analysis and rational interpretation of diverse, multifaceted data sets.
• Excellent ability to multitask, support multiple projects in parallel, and adhere to ambitious timelines.
• Efficient working knowledge of operational and scientific software programs, including Benchling, Geneious, GraphPad Prism, and Illustrator.
• Excellent communication skills (both written and oral) with demonstrated ability to present ideas, information, and data effectively to diverse audiences.
• Strong work ethic, flexibility, and collaborative mindset .
• Must be legally authorized to work in the U.S. and able to report daily to our Berkeley, CA-based lab.
• Hands-on experience in mouse handling and basic in vivo experimental techniques.
• Experience with designing and executing computational approaches for next-generation sequencing analysis.

Preferred Qualifications:

• Proficiency in Python and R coding languages for data analysis.

Desired Skills and Experience

molecular biology, cellular biology, virology, biochemistry, bioengineering, Benchling, Geneious, GraphPad Prism, Illustrator

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